Decoding F508del Misfolding in Cystic Fibrosis
نویسندگان
چکیده
منابع مشابه
Decoding F508del Misfolding in Cystic Fibrosis
The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis. The deletion of a phenylalanine at residue 508 (F508del) is the most common cause of CFTR misfolding leading to the disease. The F508del misfolding originates in the first nucleotide-binding domain (NBD1), which induces a g...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2014
ISSN: 2218-273X
DOI: 10.3390/biom4020498